Assay Detail
Functional
CHEMBL924510
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Agonist activity at human beta-3 adrenergic receptor expressed in CHO cells assessed as cAMP level
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Potent oxindole based human beta3 adrenergic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.88 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251579 | — | — | 1 | 8.57 |
| CHEMBL251372 | — | — | 1 | 8.28 |
| CHEMBL248547 | — | — | 1 | 8.18 |
| CHEMBL248751 | — | — | 1 | 8.08 |
| CHEMBL430392 | — | — | 1 | 7.97 |
| CHEMBL404626 | — | — | 1 | 7.92 |
| CHEMBL401335 | — | — | 1 | 7.91 |
| CHEMBL251176 | — | — | 1 | 7.86 |
| CHEMBL251177 | — | — | 1 | 7.85 |
| CHEMBL248750 | — | — | 1 | 7.75 |
| CHEMBL251167 | — | — | 1 | 7.61 |
| CHEMBL250579 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251579 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL251372 | — | EC50 | = | 5.2 | nM | 8.28 |
| CHEMBL248547 | — | EC50 | = | 6.6 | nM | 8.18 |
| CHEMBL248751 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL430392 | — | EC50 | = | 10.6 | nM | 7.97 |
| CHEMBL404626 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL401335 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL251176 | — | EC50 | = | 13.9 | nM | 7.86 |
| CHEMBL251177 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL248750 | — | EC50 | = | 17.6 | nM | 7.75 |
| CHEMBL251167 | — | EC50 | = | 24.4 | nM | 7.61 |
| CHEMBL250579 | — | EC50 | = | 268.1 | nM | 6.57 |