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Compound Detail

CHEMBL401335

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CC(C)(Cc1ccc(Oc2ccc(C(N)=O)cn2)cc1)NC[C@H](O)COc1cccc2c1C(Cc1ccccc1)C(=O)N2

Basic Information

ChEMBL ID CHEMBL401335
Phase Preclinical
Structure Type MOL
InChI Key NNYKUVQEGQHDMX-PVCWFJFTSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

580.7
MW (Da)
4.60
ALogP
7
HBA
4
HBD
135.8
PSA (Ų)
0.18
QED
1
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C34H36N4O5
MW 580.69
Aromatic Rings 4
Heavy Atoms 43
NP-Likeness -0.61

Activity Summary

EC50 1 meas. best 7.91

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.91 7.91 12.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17911024 10.1016/j.bmcl.2007.09.011 Beta-3 adrenergic receptor 2
17911024 10.1016/j.bmcl.2007.09.011 Beta-2 adrenergic receptor 2
17911024 10.1016/j.bmcl.2007.09.011 Beta-1 adrenergic receptor 2
17911024 10.1016/j.bmcl.2007.09.011 Atrium 1

Data from ChEMBL 36 via Core Engine