Assay Detail
Binding
CHEMBL924747
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Inhibition of GAL4-tagged RORalpha by luciferase assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.88 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261115 | — | — | 1 | 5.78 |
| CHEMBL261114 | — | — | 1 | 5.49 |
| CHEMBL260419 | — | — | 1 | 4.67 |
| CHEMBL265938 | — | — | 1 | 4.65 |
| CHEMBL408947 | — | — | 1 | 4.60 |
| CHEMBL411889 | — | — | 1 | 4.51 |
| CHEMBL412079 | — | — | 1 | 4.44 |
| CHEMBL408702 | — | — | 1 | - |
| CHEMBL412080 | — | — | 1 | - |
| CHEMBL261113 | — | — | 1 | - |
| CHEMBL259067 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261115 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL261114 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL260419 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL265938 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL408947 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL411889 | — | IC50 | = | 30700.0 | nM | 4.51 |
| CHEMBL412079 | — | IC50 | = | 36500.0 | nM | 4.44 |
| CHEMBL408702 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL412080 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL261113 | — | IC50 | > | 33000.0 | nM | - |
| CHEMBL259067 | — | IC50 | > | 33000.0 | nM | - |