Assay Detail
Binding
CHEMBL924949
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Inhibition of MMP1
142
Total Activities
142
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 129 | 6.72 | 8.64 |
| Ki | 13 | 4.32 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318860 | — | — | 1 | 8.64 |
| CHEMBL293503 | — | — | 1 | 8.52 |
| CHEMBL123775 | — | — | 1 | 8.40 |
| CHEMBL122711 | — | — | 1 | 8.22 |
| CHEMBL340461 | — | — | 1 | 8.22 |
| CHEMBL98770 | — | — | 1 | 8.17 |
| CHEMBL306726 | — | — | 1 | 8.16 |
| CHEMBL332755 | — | — | 1 | 8.15 |
| CHEMBL123463 | — | — | 1 | 8.15 |
| CHEMBL262676 | — | — | 1 | 8.15 |
| CHEMBL96637 | — | — | 1 | 8.05 |
| CHEMBL432223 | — | — | 1 | 8.00 |
| CHEMBL398271 | — | — | 1 | 7.85 |
| CHEMBL331311 | — | — | 1 | 7.80 |
| CHEMBL27408 | — | — | 1 | 7.68 |
| CHEMBL330857 | — | — | 1 | 7.68 |
| CHEMBL304281 | — | — | 1 | 7.62 |
| CHEMBL287632 | — | — | 1 | 7.62 |
| CHEMBL332120 | — | — | 1 | 7.60 |
| CHEMBL122719 | — | — | 1 | 7.60 |
| CHEMBL282581 | — | — | 1 | 7.60 |
| CHEMBL123041 | — | — | 1 | 7.59 |
| CHEMBL293774 | — | — | 1 | 7.55 |
| CHEMBL99103 | — | — | 1 | 7.55 |
| CHEMBL441084 | — | — | 1 | 7.52 |
| CHEMBL251253 | — | — | 1 | 7.51 |
| CHEMBL284422 | — | — | 1 | 7.44 |
| CHEMBL122831 | — | — | 1 | 7.43 |
| CHEMBL251687 | — | — | 1 | 7.43 |
| CHEMBL25788 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318860 | — | IC50 | = | 2.291 | nM | 8.64 |
| CHEMBL293503 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL123775 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL340461 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL122711 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL98770 | — | IC50 | = | 6.761 | nM | 8.17 |
| CHEMBL306726 | — | IC50 | = | 6.918 | nM | 8.16 |
| CHEMBL332755 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL123463 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL262676 | — | IC50 | = | 7.079 | nM | 8.15 |
| CHEMBL96637 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL432223 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL398271 | — | IC50 | = | 14.13 | nM | 7.85 |
| CHEMBL331311 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL330857 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL27408 | — | IC50 | = | 20.89 | nM | 7.68 |
| CHEMBL287632 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL304281 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL122719 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL332120 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL282581 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL123041 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL99103 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL293774 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL441084 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL251253 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL284422 | — | IC50 | = | 36.31 | nM | 7.44 |
| CHEMBL251687 | — | IC50 | = | 37.15 | nM | 7.43 |
| CHEMBL25788 | — | IC50 | = | 37.15 | nM | 7.43 |
| CHEMBL122831 | — | IC50 | = | 37.15 | nM | 7.43 |
| CHEMBL450327 | — | IC50 | = | 38.9 | nM | 7.41 |
| CHEMBL29801 | — | IC50 | = | 40.74 | nM | 7.39 |
| CHEMBL311336 | — | IC50 | = | 42.66 | nM | 7.37 |
| CHEMBL331342 | — | IC50 | = | 43.65 | nM | 7.36 |
| CHEMBL254401 | — | IC50 | = | 44.67 | nM | 7.35 |
| CHEMBL34808 | — | IC50 | = | 45.71 | nM | 7.34 |
| CHEMBL440714 | — | IC50 | = | 52.48 | nM | 7.28 |
| CHEMBL122651 | — | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL316169 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL82868 | — | IC50 | = | 60.26 | nM | 7.22 |
| CHEMBL122836 | — | IC50 | = | 60.26 | nM | 7.22 |
| CHEMBL254400 | — | IC50 | = | 60.26 | nM | 7.22 |
| CHEMBL55110 | — | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL316298 | — | IC50 | = | 61.66 | nM | 7.21 |
| CHEMBL38352 | — | IC50 | = | 64.57 | nM | 7.19 |
| CHEMBL30055 | — | IC50 | = | 72.44 | nM | 7.14 |
| CHEMBL285546 | — | IC50 | = | 75.86 | nM | 7.12 |
| CHEMBL287820 | — | IC50 | = | 77.62 | nM | 7.11 |
| CHEMBL438692 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL35433 | — | IC50 | = | 100.0 | nM | 7.00 |