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Assay Detail

CHEMBL924951

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Binding
Inhibition of MMP9
ChEMBL ↗
95
Total Activities
95
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Matrix metalloproteinase-9 (CHEMBL321) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.
Verma RP, Hansch C.
Bioorg Med Chem (2007) 15 : 2223 -2268
PubMed 17275314 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 50 6.33 8.70
Ki 45 8.04 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL293503 — — 1 9.22
CHEMBL123775 — — 1 9.22
CHEMBL180616 — — 1 9.14
CHEMBL180275 — — 1 9.14
CHEMBL306726 — — 1 9.00
CHEMBL340461 — — 1 8.96
CHEMBL359716 — — 1 8.92
CHEMBL332755 — — 1 8.92
CHEMBL262676 — — 1 8.92
CHEMBL122711 — — 1 8.89
CHEMBL331342 — — 1 8.89
CHEMBL123463 — — 1 8.85
CHEMBL122836 — — 1 8.82
CHEMBL432223 — — 1 8.77
CHEMBL178163 — — 1 8.72
CHEMBL80272 — — 1 8.70
CHEMBL55110 — — 1 8.70
CHEMBL331311 — — 1 8.40
CHEMBL80300 — — 1 8.40
CHEMBL96637 — — 1 8.40
CHEMBL123041 — — 1 8.37
CHEMBL330857 — — 1 8.37
CHEMBL304281 — — 1 8.36
CHEMBL122719 — — 1 8.34
CHEMBL178509 — — 1 8.33
CHEMBL441084 — — 1 8.30
CHEMBL70176 — — 1 8.30
CHEMBL122831 — — 1 8.30
CHEMBL76974 — — 1 8.22
CHEMBL361527 — — 1 8.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL293503 — Ki = 0.6026 nM 9.22
CHEMBL123775 — Ki = 0.6026 nM 9.22
CHEMBL180616 — Ki = 0.7244 nM 9.14
CHEMBL180275 — Ki = 0.7244 nM 9.14
CHEMBL306726 — Ki = 1.0 nM 9.00
CHEMBL340461 — Ki = 1.096 nM 8.96
CHEMBL359716 — Ki = 1.202 nM 8.92
CHEMBL332755 — Ki = 1.202 nM 8.92
CHEMBL262676 — Ki = 1.202 nM 8.92
CHEMBL122711 — Ki = 1.288 nM 8.89
CHEMBL331342 — Ki = 1.288 nM 8.89
CHEMBL123463 — Ki = 1.413 nM 8.85
CHEMBL122836 — Ki = 1.514 nM 8.82
CHEMBL432223 — Ki = 1.698 nM 8.77
CHEMBL178163 — Ki = 1.905 nM 8.72
CHEMBL80272 — IC50 = 1.995 nM 8.70
CHEMBL55110 — Ki = 1.995 nM 8.70
CHEMBL331311 — Ki = 3.981 nM 8.40
CHEMBL80300 — IC50 = 3.981 nM 8.40
CHEMBL96637 — IC50 = 3.981 nM 8.40
CHEMBL123041 — Ki = 4.266 nM 8.37
CHEMBL330857 — Ki = 4.266 nM 8.37
CHEMBL304281 — Ki = 4.365 nM 8.36
CHEMBL122719 — Ki = 4.571 nM 8.34
CHEMBL178509 — Ki = 4.677 nM 8.33
CHEMBL441084 — Ki = 5.012 nM 8.30
CHEMBL122831 — Ki = 5.012 nM 8.30
CHEMBL70176 — IC50 = 5.012 nM 8.30
CHEMBL76974 — IC50 = 6.026 nM 8.22
CHEMBL361527 — Ki = 7.244 nM 8.14
CHEMBL94357 — IC50 = 10.96 nM 7.96
CHEMBL98061 — IC50 = 10.96 nM 7.96
CHEMBL311368 — IC50 = 12.88 nM 7.89
CHEMBL316298 — IC50 = 14.13 nM 7.85
CHEMBL311509 — IC50 = 22.91 nM 7.64
CHEMBL76606 — IC50 = 22.91 nM 7.64
CHEMBL450327 — Ki = 23.99 nM 7.62
CHEMBL311336 — Ki = 26.92 nM 7.57
CHEMBL308084 — IC50 = 26.92 nM 7.57
CHEMBL332120 — Ki = 28.18 nM 7.55
CHEMBL293774 — Ki = 30.9 nM 7.51
CHEMBL307182 — IC50 = 30.9 nM 7.51
CHEMBL440714 — Ki = 30.9 nM 7.51
CHEMBL316169 — Ki = 34.67 nM 7.46
CHEMBL123443 — Ki = 36.31 nM 7.44
CHEMBL122651 — Ki = 38.9 nM 7.41
CHEMBL92927 — IC50 = 39.81 nM 7.40
CHEMBL328751 — IC50 = 41.69 nM 7.38
CHEMBL82868 — Ki = 41.69 nM 7.38
CHEMBL80894 — IC50 = 64.57 nM 7.19