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Assay Detail

CHEMBL925055

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Binding
Inhibition of adenylyl cyclase
ChEMBL ↗
46
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors.
Wang JL, Guo JX, Zhang QY, Wu JJ, Seifert R, Lushington GH.
Bioorg Med Chem (2007) 15 : 2993 -3002
PubMed 17329110 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 46 6.04 8.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL403351 — — 2 8.38
CHEMBL254451 — — 2 7.72
CHEMBL400551 — — 2 7.70
CHEMBL401485 — — 2 7.62
CHEMBL398768 — — 2 7.47
CHEMBL254869 — — 2 7.46
CHEMBL255082 — — 2 7.35
CHEMBL399755 — — 2 7.24
CHEMBL430399 — — 2 6.70
CHEMBL398769 — — 2 6.54
CHEMBL398767 — — 2 6.48
CHEMBL251971 — — 2 6.34
CHEMBL252167 — — 2 5.92
CHEMBL400999 — — 2 5.85
CHEMBL398770 — — 2 5.47
CHEMBL252169 — — 2 5.24
CHEMBL220200 — — 2 5.07
CHEMBL252375 — — 2 4.37
CHEMBL253606 — — 2 4.10
CHEMBL252573 — — 2 4.00
CHEMBL399171 — — 2 4.00
CHEMBL252777 — — 2 4.00
CHEMBL336296 URIDINE TRIPHOSPHATE 3.0 2 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL403351 — Ki = 4.2 nM 8.38
CHEMBL403351 — Ki = 4.169 nM 8.38
CHEMBL254451 — Ki = 19.0 nM 7.72
CHEMBL254451 — Ki = 19.05 nM 7.72
CHEMBL400551 — Ki = 19.95 nM 7.70
CHEMBL400551 — Ki = 20.0 nM 7.70
CHEMBL401485 — Ki = 24.0 nM 7.62
CHEMBL401485 — Ki = 23.99 nM 7.62
CHEMBL398768 — Ki = 33.88 nM 7.47
CHEMBL398768 — Ki = 34.0 nM 7.47
CHEMBL254869 — Ki = 34.67 nM 7.46
CHEMBL254869 — Ki = 35.0 nM 7.46
CHEMBL255082 — Ki = 45.0 nM 7.35
CHEMBL255082 — Ki = 44.67 nM 7.35
CHEMBL399755 — Ki = 57.54 nM 7.24
CHEMBL399755 — Ki = 57.0 nM 7.24
CHEMBL430399 — Ki = 199.53 nM 6.70
CHEMBL430399 — Ki = 200.0 nM 6.70
CHEMBL398769 — Ki = 288.4 nM 6.54
CHEMBL398769 — Ki = 290.0 nM 6.54
CHEMBL398767 — Ki = 331.13 nM 6.48
CHEMBL398767 — Ki = 330.0 nM 6.48
CHEMBL251971 — Ki = 460.0 nM 6.34
CHEMBL251971 — Ki = 457.09 nM 6.34
CHEMBL252167 — Ki = 1200.0 nM 5.92
CHEMBL252167 — Ki = 1202.26 nM 5.92
CHEMBL400999 — Ki = 1412.54 nM 5.85
CHEMBL400999 — Ki = 1400.0 nM 5.85
CHEMBL398770 — Ki = 3388.44 nM 5.47
CHEMBL398770 — Ki = 3400.0 nM 5.47
CHEMBL252169 — Ki = 5754.4 nM 5.24
CHEMBL252169 — Ki = 5800.0 nM 5.24
CHEMBL220200 — Ki = 8511.38 nM 5.07
CHEMBL220200 — Ki = 8500.0 nM 5.07
CHEMBL252375 — Ki = 42657.95 nM 4.37
CHEMBL252375 — Ki = 43000.0 nM 4.37
CHEMBL253606 — Ki = 79432.82 nM 4.10
CHEMBL253606 — Ki = 79000.0 nM 4.10
CHEMBL336296 URIDINE TRIPHOSPHATE Ki = 100000.0 nM 4.00
CHEMBL336296 URIDINE TRIPHOSPHATE Ki = 100000.0 nM 4.00
CHEMBL252777 — Ki = 100000.0 nM 4.00
CHEMBL252573 — Ki = 100000.0 nM 4.00
CHEMBL252573 — Ki = 100000.0 nM 4.00
CHEMBL399171 — Ki = 100000.0 nM 4.00
CHEMBL399171 — Ki = 100000.0 nM 4.00
CHEMBL252777 — Ki = 100000.0 nM 4.00