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Assay Detail

CHEMBL925057

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Binding
Inhibition of Candida albicans N-myristoyltransferse
ChEMBL ↗
94
Total Activities
47
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Candida albicans
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Glycylpeptide N-tetradecanoyltransferase (CHEMBL3548) ↗
Type SINGLE PROTEIN
Organism Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Publication

3D-QSAR and molecular docking studies on benzothiazole derivatives as Candida albicans N-myristoyltransferase inhibitors.
Sheng C, Zhu J, Zhang W, Zhang M, Ji H, Song Y, Xu H, Yao J, Miao Z, Zhou Y, Zhu J, Lü J.
Eur J Med Chem (2007) 42 : 477 -486
PubMed 17349719 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 7.23 9.41
Log IC50 47 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL170807 — — 2 9.41
CHEMBL253804 — — 2 9.31
CHEMBL254011 — — 2 8.64
CHEMBL400892 — — 2 8.62
CHEMBL254010 — — 2 8.48
CHEMBL347048 — — 2 8.24
CHEMBL401095 — — 2 8.09
CHEMBL253587 — — 2 7.96
CHEMBL399663 — — 2 7.82
CHEMBL252957 — — 2 7.64
CHEMBL252142 — — 2 7.58
CHEMBL401272 — — 2 7.55
CHEMBL254220 — — 2 7.47
CHEMBL253350 — — 2 7.47
CHEMBL252752 — — 2 7.34
CHEMBL251943 — — 2 7.19
CHEMBL253352 — — 2 7.13
CHEMBL253351 — — 2 6.96
CHEMBL253803 — — 2 6.89
CHEMBL252751 — — 2 6.89
CHEMBL253162 — — 2 6.80
CHEMBL253586 — — 2 6.80
CHEMBL251944 — — 2 6.72
CHEMBL252143 — — 2 6.68
CHEMBL429491 — — 2 6.52
CHEMBL253585 — — 2 6.51
CHEMBL251945 — — 2 6.30
CHEMBL434276 — — 2 6.21
CHEMBL253164 — — 2 6.14
CHEMBL252958 — — 2 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL170807 — IC50 = 0.39 nM 9.41
CHEMBL253804 — IC50 = 0.49 nM 9.31
CHEMBL254011 — IC50 = 2.3 nM 8.64
CHEMBL400892 — IC50 = 2.4 nM 8.62
CHEMBL254010 — IC50 = 3.3 nM 8.48
CHEMBL347048 — IC50 = 5.7 nM 8.24
CHEMBL401095 — IC50 = 8.1 nM 8.09
CHEMBL253587 — IC50 = 11.0 nM 7.96
CHEMBL399663 — IC50 = 15.0 nM 7.82
CHEMBL252957 — IC50 = 23.0 nM 7.64
CHEMBL252142 — IC50 = 26.0 nM 7.58
CHEMBL401272 — IC50 = 28.0 nM 7.55
CHEMBL253350 — IC50 = 34.0 nM 7.47
CHEMBL254220 — IC50 = 34.0 nM 7.47
CHEMBL252752 — IC50 = 46.0 nM 7.34
CHEMBL251943 — IC50 = 65.0 nM 7.19
CHEMBL253352 — IC50 = 74.0 nM 7.13
CHEMBL253351 — IC50 = 110.0 nM 6.96
CHEMBL252751 — IC50 = 130.0 nM 6.89
CHEMBL253803 — IC50 = 130.0 nM 6.89
CHEMBL253586 — IC50 = 160.0 nM 6.80
CHEMBL253162 — IC50 = 160.0 nM 6.80
CHEMBL251944 — IC50 = 190.0 nM 6.72
CHEMBL252143 — IC50 = 210.0 nM 6.68
CHEMBL429491 — IC50 = 300.0 nM 6.52
CHEMBL253585 — IC50 = 310.0 nM 6.51
CHEMBL251945 — IC50 = 500.0 nM 6.30
CHEMBL434276 — IC50 = 620.0 nM 6.21
CHEMBL253164 — IC50 = 730.0 nM 6.14
CHEMBL252958 — IC50 = 890.0 nM 6.05
CHEMBL53935 — IC50 = 1700.0 nM 5.77
CHEMBL252060 — IC50 = 1900.0 nM 5.72
CHEMBL252144 — IC50 = 2300.0 nM 5.64
CHEMBL251927 — IC50 > 10000.0 nM -
CHEMBL252060 — Log IC50 = 0.279 uM -
CHEMBL252144 — Log IC50 = -0.362 uM -
CHEMBL252347 — Log IC50 = -1.0 uM -
CHEMBL252347 — IC50 > 10000.0 nM -
CHEMBL252349 — Log IC50 = -1.0 uM -
CHEMBL252349 — IC50 > 10000.0 nM -
CHEMBL252750 — Log IC50 = -1.0 uM -
CHEMBL401271 — IC50 > 10000.0 nM -
CHEMBL401271 — Log IC50 = -1.0 uM -
CHEMBL252143 — Log IC50 = 0.678 uM -
CHEMBL252546 — Log IC50 = - uM -
CHEMBL252545 — IC50 > 10000.0 nM -
CHEMBL252546 — IC50 > 1000.0 nM -
CHEMBL252544 — Log IC50 = -1.0 uM -
CHEMBL252545 — Log IC50 = -1.0 uM -
CHEMBL252544 — IC50 > 10000.0 nM -