Assay Detail
Functional
CHEMBL925070
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 10.19 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363840 | — | — | 1 | 11.00 |
| CHEMBL195433 | — | — | 1 | 10.52 |
| CHEMBL250689 | — | — | 1 | 10.47 |
| CHEMBL249854 | — | — | 1 | 10.17 |
| CHEMBL251079 | — | — | 1 | 10.12 |
| CHEMBL250056 | — | — | 1 | 10.00 |
| CHEMBL249057 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363840 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL195433 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL250689 | — | IC50 | = | 0.034 | nM | 10.47 |
| CHEMBL249854 | — | IC50 | = | 0.068 | nM | 10.17 |
| CHEMBL251079 | — | IC50 | = | 0.075 | nM | 10.12 |
| CHEMBL250056 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL249057 | — | IC50 | = | 0.9 | nM | 9.05 |