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Assay Detail

CHEMBL925134

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Binding
Inhibition of thyroid hormone receptor alpha
ChEMBL ↗
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Thyroid hormone receptor alpha (CHEMBL1860) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2D QSAR studies on thyroid hormone receptor ligands.
Valadares NF, Castilho MS, Polikarpov I, Garratt RC.
Bioorg Med Chem (2007) 15 : 4609 -4617
PubMed 17467994 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 68 6.84 10.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291053 THYROPROPIC ACID 2.0 1 10.39
CHEMBL289343 — — 1 10.00
CHEMBL41632 TIRATRICOL 3.0 1 9.85
CHEMBL41314 — — 1 9.85
CHEMBL557 DETROTHYRONINE 2.0 1 9.62
CHEMBL418432 — — 1 9.12
CHEMBL203777 — — 1 8.85
CHEMBL39174 — — 1 8.81
CHEMBL425939 — — 1 8.60
CHEMBL289965 — — 1 8.01
CHEMBL251456 — — 1 7.89
CHEMBL235609 — — 1 7.82
CHEMBL235177 — — 1 7.74
CHEMBL442280 — — 1 7.74
CHEMBL41036 — — 1 7.60
CHEMBL236436 — — 1 7.52
CHEMBL401392 — — 1 7.42
CHEMBL442243 — — 1 7.40
CHEMBL235384 — — 1 7.30
CHEMBL249445 — — 1 7.07
CHEMBL238178 — — 1 7.03
CHEMBL392925 — — 1 7.02
CHEMBL236438 — — 1 7.00
CHEMBL393489 — — 1 6.91
CHEMBL235165 — — 1 6.91
CHEMBL254607 — — 1 6.90
CHEMBL40738 — — 1 6.89
CHEMBL235788 — — 1 6.89
CHEMBL428729 — — 1 6.84
CHEMBL203555 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291053 THYROPROPIC ACID IC50 = 0.04074 nM 10.39
CHEMBL289343 — IC50 = 0.1 nM 10.00
CHEMBL41314 — IC50 = 0.1413 nM 9.85
CHEMBL41632 TIRATRICOL IC50 = 0.1413 nM 9.85
CHEMBL557 DETROTHYRONINE IC50 = 0.2399 nM 9.62
CHEMBL418432 — IC50 = 0.7586 nM 9.12
CHEMBL203777 — IC50 = 1.413 nM 8.85
CHEMBL39174 — IC50 = 1.549 nM 8.81
CHEMBL425939 — IC50 = 2.512 nM 8.60
CHEMBL289965 — IC50 = 9.772 nM 8.01
CHEMBL251456 — IC50 = 12.88 nM 7.89
CHEMBL235609 — IC50 = 15.14 nM 7.82
CHEMBL235177 — IC50 = 18.2 nM 7.74
CHEMBL442280 — IC50 = 18.2 nM 7.74
CHEMBL41036 — IC50 = 25.12 nM 7.60
CHEMBL236436 — IC50 = 30.2 nM 7.52
CHEMBL401392 — IC50 = 38.02 nM 7.42
CHEMBL442243 — IC50 = 39.81 nM 7.40
CHEMBL235384 — IC50 = 50.12 nM 7.30
CHEMBL249445 — IC50 = 85.11 nM 7.07
CHEMBL238178 — IC50 = 93.33 nM 7.03
CHEMBL392925 — IC50 = 95.5 nM 7.02
CHEMBL236438 — IC50 = 100.0 nM 7.00
CHEMBL393489 — IC50 = 123.03 nM 6.91
CHEMBL235165 — IC50 = 123.03 nM 6.91
CHEMBL254607 — IC50 = 125.89 nM 6.90
CHEMBL235788 — IC50 = 128.82 nM 6.89
CHEMBL40738 — IC50 = 128.82 nM 6.89
CHEMBL428729 — IC50 = 144.54 nM 6.84
CHEMBL203555 — IC50 = 199.53 nM 6.70
CHEMBL235816 — IC50 = 204.17 nM 6.69
CHEMBL237958 — IC50 = 229.09 nM 6.64
CHEMBL235607 — IC50 = 239.88 nM 6.62
CHEMBL235383 — IC50 = 245.47 nM 6.61
CHEMBL378593 — IC50 = 251.19 nM 6.60
CHEMBL237936 — IC50 = 269.15 nM 6.57
CHEMBL429078 — IC50 = 281.84 nM 6.55
CHEMBL394644 — IC50 = 295.12 nM 6.53
CHEMBL251090 — IC50 = 338.84 nM 6.47
CHEMBL235608 — IC50 = 426.58 nM 6.37
CHEMBL252717 — IC50 = 457.09 nM 6.34
CHEMBL442082 — IC50 = 457.09 nM 6.34
CHEMBL394199 — IC50 = 501.19 nM 6.30
CHEMBL235385 — IC50 = 549.54 nM 6.26
CHEMBL235164 — IC50 = 562.34 nM 6.25
CHEMBL251439 — IC50 = 616.6 nM 6.21
CHEMBL204609 — IC50 = 616.6 nM 6.21
CHEMBL202940 — IC50 = 630.96 nM 6.20
CHEMBL237722 — IC50 = 812.83 nM 6.09
CHEMBL236864 — IC50 = 851.14 nM 6.07