Assay Detail
Binding
CHEMBL925137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of porcine pancreatic elastase
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.72 | 6.16 |
| IC50 | 3 | 6.65 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2304256 | SCYPTOLIN A | — | 1 | 6.80 |
| CHEMBL437538 | — | — | 1 | 6.58 |
| CHEMBL403896 | — | — | 1 | 6.57 |
| CHEMBL254314 | — | — | 1 | 6.16 |
| CHEMBL401765 | — | — | 1 | 5.82 |
| CHEMBL401731 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2304256 | SCYPTOLIN A | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL437538 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL403896 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL254314 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL401765 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL401731 | — | Ki | = | 6700.0 | nM | 5.17 |