Assay Detail
Binding
CHEMBL925141
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Inhibition of human carbonic anhydrase 1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrases as targets for medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.93 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253997 | — | — | 1 | 8.52 |
| CHEMBL120304 | — | — | 1 | 8.52 |
| CHEMBL254835 | — | — | 1 | 8.40 |
| CHEMBL438693 | — | — | 1 | 8.40 |
| CHEMBL254834 | — | — | 1 | 8.15 |
| CHEMBL255047 | — | — | 1 | 8.10 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL430213 | — | — | 1 | 7.40 |
| CHEMBL254833 | — | — | 1 | 7.30 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL399457 | — | — | 1 | 7.22 |
| CHEMBL253362 | — | — | 1 | 6.75 |
| CHEMBL254211 | — | — | 1 | 6.70 |
| CHEMBL400889 | — | — | 1 | 6.70 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.60 |
| CHEMBL254212 | — | — | 1 | 6.21 |
| CHEMBL254005 | — | — | 1 | 5.96 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL283695 | — | — | 1 | 5.46 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 4.35 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253997 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL120304 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL254835 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL438693 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL254834 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL255047 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL430213 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL254833 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL399457 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL253362 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL254211 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL400889 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL254212 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL254005 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL283695 | — | Ki | = | 3450.0 | nM | 5.46 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |