Assay Detail
Binding
CHEMBL925143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 3
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrases as targets for medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.97 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.96 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.51 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 5.30 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 5.10 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | - |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | - |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | - |
| CHEMBL283695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | - | — | - | |
| CHEMBL220491 | BRINZOLAMIDE | Ki | - | — | - | |
| CHEMBL220492 | TOPIRAMATE | Ki | - | — | - | |
| CHEMBL283695 | — | Ki | - | — | - |