Assay Detail
Binding
CHEMBL925144
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Inhibition of human carbonic anhydrase 4
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrases as targets for medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.80 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.13 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.03 |
| CHEMBL283695 | — | — | 1 | 6.03 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 5.31 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 5.21 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 5.07 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 4.82 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL283695 | — | Ki | = | 941.0 | nM | 6.03 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | - | — | - |