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Assay Detail

CHEMBL925153

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovin carbonic anhydrase 4
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Carbonic anhydrase 4 (CHEMBL281)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Carbonic anhydrases as targets for medicinal chemistry.
Supuran CT, Scozzafava A.
Bioorg Med Chem (2007) 15 : 4336 -4350
PubMed 17475500 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 7.61 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL253997 1 8.10
CHEMBL254211 1 8.10
CHEMBL254212 1 8.00
CHEMBL400889 1 8.00
CHEMBL438693 1 7.96
CHEMBL253362 1 7.92
CHEMBL255047 1 7.85
CHEMBL120304 1 7.70
CHEMBL254834 1 7.62
CHEMBL254835 1 7.60
CHEMBL254833 1 7.16
CHEMBL430213 1 6.92
CHEMBL254005 1 6.85
CHEMBL399457 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL253997 Ki = 8.0 nM 8.10
CHEMBL254211 Ki = 8.0 nM 8.10
CHEMBL254212 Ki = 10.0 nM 8.00
CHEMBL400889 Ki = 10.0 nM 8.00
CHEMBL438693 Ki = 11.0 nM 7.96
CHEMBL253362 Ki = 12.0 nM 7.92
CHEMBL255047 Ki = 14.0 nM 7.85
CHEMBL120304 Ki = 20.0 nM 7.70
CHEMBL254834 Ki = 24.0 nM 7.62
CHEMBL254835 Ki = 25.0 nM 7.60
CHEMBL254833 Ki = 70.0 nM 7.16
CHEMBL430213 Ki = 120.0 nM 6.92
CHEMBL254005 Ki = 140.0 nM 6.85
CHEMBL399457 Ki = 160.0 nM 6.80