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Assay Detail

CHEMBL925154

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Binding
Inhibition of human recombinant MCD
ChEMBL ↗
150
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Malonyl-CoA decarboxylase, mitochondrial (CHEMBL4698) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

3D-QSAR studies on malonyl coenzyme A decarboxylase inhibitors.
Patel MR, Talele TT.
Bioorg Med Chem (2007) 15 : 4470 -4481
PubMed 17482825 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 150 6.96 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL380868 — — 2 8.10
CHEMBL400455 — — 2 8.10
CHEMBL203790 — — 2 7.72
CHEMBL210190 — — 2 7.70
CHEMBL382695 — — 2 7.70
CHEMBL206438 — — 2 7.70
CHEMBL202632 — — 2 7.59
CHEMBL381996 — — 2 7.55
CHEMBL202905 — — 2 7.52
CHEMBL381564 — — 2 7.51
CHEMBL205932 — — 2 7.47
CHEMBL203991 — — 2 7.43
CHEMBL377710 — — 2 7.43
CHEMBL380746 — — 2 7.40
CHEMBL201846 — — 2 7.39
CHEMBL383478 — — 2 7.39
CHEMBL385355 — — 2 7.38
CHEMBL206562 — — 2 7.38
CHEMBL205117 — — 2 7.37
CHEMBL252977 — — 2 7.36
CHEMBL211767 — — 2 7.27
CHEMBL370452 — — 2 7.23
CHEMBL202161 — — 2 7.19
CHEMBL205986 — — 2 7.15
CHEMBL205719 — — 2 7.14
CHEMBL205931 — — 2 7.13
CHEMBL382246 — — 2 7.12
CHEMBL370451 — — 2 7.06
CHEMBL382794 — — 2 7.02
CHEMBL203871 — — 2 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL380868 — IC50 = 8.0 nM 8.10
CHEMBL380868 — IC50 = 7.943 nM 8.10
CHEMBL400455 — IC50 = 8.0 nM 8.10
CHEMBL400455 — IC50 = 7.943 nM 8.10
CHEMBL203790 — IC50 = 19.05 nM 7.72
CHEMBL203790 — IC50 = 19.0 nM 7.72
CHEMBL206438 — IC50 = 19.95 nM 7.70
CHEMBL206438 — IC50 = 20.0 nM 7.70
CHEMBL382695 — IC50 = 19.95 nM 7.70
CHEMBL382695 — IC50 = 20.0 nM 7.70
CHEMBL210190 — IC50 = 20.0 nM 7.70
CHEMBL210190 — IC50 = 19.95 nM 7.70
CHEMBL202632 — IC50 = 25.7 nM 7.59
CHEMBL202632 — IC50 = 26.0 nM 7.58
CHEMBL381996 — IC50 = 28.0 nM 7.55
CHEMBL381996 — IC50 = 28.18 nM 7.55
CHEMBL202905 — IC50 = 30.0 nM 7.52
CHEMBL202905 — IC50 = 30.2 nM 7.52
CHEMBL381564 — IC50 = 30.9 nM 7.51
CHEMBL381564 — IC50 = 31.0 nM 7.51
CHEMBL205932 — IC50 = 33.88 nM 7.47
CHEMBL205932 — IC50 = 34.0 nM 7.47
CHEMBL377710 — IC50 = 37.15 nM 7.43
CHEMBL203991 — IC50 = 37.15 nM 7.43
CHEMBL203991 — IC50 = 37.0 nM 7.43
CHEMBL380746 — IC50 = 40.0 nM 7.40
CHEMBL383478 — IC50 = 40.74 nM 7.39
CHEMBL201846 — IC50 = 40.74 nM 7.39
CHEMBL383478 — IC50 = 41.0 nM 7.39
CHEMBL385355 — IC50 = 42.0 nM 7.38
CHEMBL206562 — IC50 = 42.0 nM 7.38
CHEMBL206562 — IC50 = 41.69 nM 7.38
CHEMBL385355 — IC50 = 41.69 nM 7.38
CHEMBL380746 — IC50 = 41.69 nM 7.38
CHEMBL205117 — IC50 = 42.66 nM 7.37
CHEMBL205117 — IC50 = 43.0 nM 7.37
CHEMBL252977 — IC50 = 43.65 nM 7.36
CHEMBL252977 — IC50 = 44.0 nM 7.36
CHEMBL211767 — IC50 = 54.0 nM 7.27
CHEMBL211767 — IC50 = 53.7 nM 7.27
CHEMBL370452 — IC50 = 58.88 nM 7.23
CHEMBL370452 — IC50 = 59.0 nM 7.23
CHEMBL202161 — IC50 = 64.57 nM 7.19
CHEMBL205986 — IC50 = 70.79 nM 7.15
CHEMBL205719 — IC50 = 73.0 nM 7.14
CHEMBL205719 — IC50 = 72.44 nM 7.14
CHEMBL205931 — IC50 = 74.0 nM 7.13
CHEMBL205931 — IC50 = 74.13 nM 7.13
CHEMBL382246 — IC50 = 75.0 nM 7.12
CHEMBL382246 — IC50 = 75.86 nM 7.12