Assay Detail
Binding
CHEMBL925269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cfms
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of novel anilinoquinolines as c-fms inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 7.12 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250571 | — | — | 1 | 8.10 |
| CHEMBL249169 | — | — | 1 | 7.80 |
| CHEMBL250364 | — | — | 1 | 7.80 |
| CHEMBL399441 | — | — | 1 | 7.80 |
| CHEMBL250161 | — | — | 1 | 7.80 |
| CHEMBL251174 | — | — | 1 | 7.60 |
| CHEMBL249139 | — | — | 1 | 7.60 |
| CHEMBL399932 | — | — | 1 | 7.50 |
| CHEMBL249138 | — | — | 1 | 7.50 |
| CHEMBL251367 | — | — | 1 | 7.50 |
| CHEMBL248933 | — | — | 1 | 7.50 |
| CHEMBL249779 | — | — | 1 | 7.50 |
| CHEMBL248740 | — | — | 1 | 7.40 |
| CHEMBL248931 | — | — | 1 | 7.40 |
| CHEMBL399739 | — | — | 1 | 7.40 |
| CHEMBL249960 | — | — | 1 | 7.30 |
| CHEMBL249163 | — | — | 1 | 7.30 |
| CHEMBL249781 | — | — | 1 | 7.30 |
| CHEMBL251173 | — | — | 1 | 7.30 |
| CHEMBL249170 | — | — | 1 | 7.20 |
| CHEMBL428228 | — | — | 1 | 7.20 |
| CHEMBL249573 | — | — | 1 | 7.20 |
| CHEMBL250572 | — | — | 1 | 7.20 |
| CHEMBL399117 | — | — | 1 | 7.10 |
| CHEMBL398469 | — | — | 1 | 7.10 |
| CHEMBL399118 | — | — | 1 | 7.10 |
| CHEMBL443587 | — | — | 1 | 7.10 |
| CHEMBL250362 | — | — | 1 | 7.10 |
| CHEMBL250775 | — | — | 1 | 7.00 |
| CHEMBL398920 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250571 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL249169 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL250364 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL399441 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL250161 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL251174 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL249139 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL249779 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL399932 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL248933 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL251367 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL249138 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL248931 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL399739 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL248740 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL249960 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL251173 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL249781 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL249163 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL249170 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL428228 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL249573 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL250572 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL399117 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL250362 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL443587 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL398469 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL399118 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL250775 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL398920 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL249544 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL249137 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL401420 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL249377 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL399647 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL250774 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL248930 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL249751 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL250160 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL399702 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL249752 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL400289 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL249371 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL249574 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL249545 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL400288 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL399703 | — | IC50 | - | — | - |