Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL925270

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition of MCSF expressing mouse M-NSF60 cells
ChEMBL ↗
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type M-NSF60
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Synthesis of novel anilinoquinolines as c-fms inhibitors.
Smalley TL, Chamberlain SD, Mills WY, Musso DL, Randhawa SA, Ray JA, Samano V, Frick L.
Bioorg Med Chem Lett (2007) 17 : 6257 -6260
PubMed 17870531 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 47 5.73 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL250571 — — 1 7.00
CHEMBL250364 — — 1 7.00
CHEMBL399117 — — 1 7.00
CHEMBL399703 — — 1 7.00
CHEMBL399739 — — 1 6.80
CHEMBL248933 — — 1 6.70
CHEMBL250362 — — 1 6.70
CHEMBL248740 — — 1 6.50
CHEMBL250774 — — 1 6.40
CHEMBL250161 — — 1 6.40
CHEMBL400289 — — 1 6.10
CHEMBL250160 — — 1 6.10
CHEMBL398920 — — 1 6.10
CHEMBL249170 — — 1 6.10
CHEMBL249169 — — 1 6.10
CHEMBL249781 — — 1 6.00
CHEMBL250775 — — 1 6.00
CHEMBL443587 — — 1 5.89
CHEMBL249751 — — 1 5.89
CHEMBL399647 — — 1 5.80
CHEMBL249960 — — 1 5.80
CHEMBL399702 — — 1 5.70
CHEMBL248930 — — 1 5.70
CHEMBL428228 — — 1 5.70
CHEMBL249779 — — 1 5.60
CHEMBL250572 — — 1 5.50
CHEMBL398469 — — 1 5.50
CHEMBL249544 — — 1 5.40
CHEMBL249137 — — 1 5.40
CHEMBL249163 — — 1 5.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL250571 — IC50 = 100.0 nM 7.00
CHEMBL399703 — IC50 = 100.0 nM 7.00
CHEMBL399117 — IC50 = 100.0 nM 7.00
CHEMBL250364 — IC50 = 100.0 nM 7.00
CHEMBL399739 — IC50 = 160.0 nM 6.80
CHEMBL248933 — IC50 = 200.0 nM 6.70
CHEMBL250362 — IC50 = 200.0 nM 6.70
CHEMBL248740 — IC50 = 320.0 nM 6.50
CHEMBL250774 — IC50 = 400.0 nM 6.40
CHEMBL250161 — IC50 = 400.0 nM 6.40
CHEMBL398920 — IC50 = 800.0 nM 6.10
CHEMBL249169 — IC50 = 800.0 nM 6.10
CHEMBL249170 — IC50 = 800.0 nM 6.10
CHEMBL250160 — IC50 = 800.0 nM 6.10
CHEMBL400289 — IC50 = 800.0 nM 6.10
CHEMBL249781 — IC50 = 1000.0 nM 6.00
CHEMBL250775 — IC50 = 1000.0 nM 6.00
CHEMBL443587 — IC50 = 1300.0 nM 5.89
CHEMBL249751 — IC50 = 1300.0 nM 5.89
CHEMBL399647 — IC50 = 1600.0 nM 5.80
CHEMBL249960 — IC50 = 1600.0 nM 5.80
CHEMBL428228 — IC50 = 2000.0 nM 5.70
CHEMBL399702 — IC50 = 2000.0 nM 5.70
CHEMBL248930 — IC50 = 2000.0 nM 5.70
CHEMBL249779 — IC50 = 2500.0 nM 5.60
CHEMBL250572 — IC50 = 3200.0 nM 5.50
CHEMBL398469 — IC50 = 3200.0 nM 5.50
CHEMBL249544 — IC50 = 4000.0 nM 5.40
CHEMBL249137 — IC50 = 4000.0 nM 5.40
CHEMBL249163 — IC50 = 4000.0 nM 5.40
CHEMBL249139 — IC50 = 5000.0 nM 5.30
CHEMBL399118 — IC50 = 5000.0 nM 5.30
CHEMBL249573 — IC50 = 6300.0 nM 5.20
CHEMBL251174 — IC50 = 6300.0 nM 5.20
CHEMBL248931 — IC50 = 6300.0 nM 5.20
CHEMBL249545 — IC50 = 8000.0 nM 5.10
CHEMBL249371 — IC50 = 8000.0 nM 5.10
CHEMBL249377 — IC50 = 10000.0 nM 5.00
CHEMBL249752 — IC50 = 10000.0 nM 5.00
CHEMBL401420 — IC50 = 16000.0 nM 4.80
CHEMBL251367 — IC50 = 25000.0 nM 4.60
CHEMBL251173 — IC50 = 32000.0 nM 4.50
CHEMBL249574 — IC50 = 40000.0 nM 4.40
CHEMBL399441 — IC50 = 50000.0 nM 4.30
CHEMBL249138 — IC50 > 20000.0 nM -
CHEMBL399932 — IC50 > 20000.0 nM -
CHEMBL400288 — IC50 > 50000.0 nM -