Assay Detail
Binding
CHEMBL925325
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Inhibition of human HDAC4 expressed in 293T cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.32 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241555 | — | — | 1 | 8.80 |
| CHEMBL394261 | — | — | 1 | 8.80 |
| CHEMBL238829 | — | — | 1 | 8.74 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.70 |
| CHEMBL393464 | — | — | 1 | 8.66 |
| CHEMBL390991 | — | — | 1 | 8.62 |
| CHEMBL391384 | — | — | 1 | 8.57 |
| CHEMBL391383 | — | — | 1 | 8.49 |
| CHEMBL393961 | — | — | 1 | 8.40 |
| CHEMBL238587 | — | — | 1 | 8.38 |
| CHEMBL238596 | — | — | 1 | 8.28 |
| CHEMBL393260 | — | — | 1 | 7.60 |
| CHEMBL428737 | — | — | 1 | 7.25 |
| CHEMBL393261 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241555 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL394261 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL238829 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL393464 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL390991 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL391384 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL391383 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL393961 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL238587 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL238596 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL393260 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL428737 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL393261 | — | IC50 | = | 70.0 | nM | 7.16 |