Assay Detail
Functional
CHEMBL925345
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Cytotoxicity against vincristine-resistant human KB/VJ300 cells in presence of 0.1 ug/mL vincristine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB/VJ300 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biologically active indole alkaloids from Kopsia arborea.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.81 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251682 | VALPARICINE | — | 1 | 5.78 |
| CHEMBL400902 | ARBOLOSCINE | — | 1 | 4.95 |
| CHEMBL251690 | VINCADIFFORMINE | — | 1 | 4.88 |
| CHEMBL251650 | — | — | 1 | 4.57 |
| CHEMBL400176 | — | — | 1 | 4.57 |
| CHEMBL251688 | ARBORICININE | — | 1 | 4.50 |
| CHEMBL400901 | ARBORICINE | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251682 | VALPARICINE | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL400902 | ARBOLOSCINE | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL251690 | VINCADIFFORMINE | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL251650 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL400176 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL251688 | ARBORICININE | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL400901 | ARBORICINE | IC50 | = | 36700.0 | nM | 4.43 |