Assay Detail
Binding
CHEMBL925661
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human thrombin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.29 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1166 | ARGATROBAN | 4.0 | 1 | 8.27 |
| CHEMBL254648 | COCHINCHINENIN B | — | 1 | 4.91 |
| CHEMBL399481 | COCHINCHINENENE B | — | 1 | 4.75 |
| CHEMBL254647 | — | — | 1 | 4.67 |
| CHEMBL251977 | — | — | 1 | 4.58 |
| CHEMBL254439 | COCHINCHINENENE C | — | 1 | 4.57 |
| CHEMBL254229 | COCHINCHINENENE A | — | 1 | - |
| CHEMBL254649 | COCHINCHINENIN C | — | 1 | - |
| CHEMBL254440 | COCHINCHINENENE D | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1166 | ARGATROBAN | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL254648 | COCHINCHINENIN B | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL399481 | COCHINCHINENENE B | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL254647 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL251977 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL254439 | COCHINCHINENENE C | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL254229 | COCHINCHINENENE A | IC50 | > | 9500.0 | nM | - |
| CHEMBL254649 | COCHINCHINENIN C | IC50 | > | 9200.0 | nM | - |
| CHEMBL254440 | COCHINCHINENENE D | IC50 | > | 41300.0 | nM | - |