Assay Detail

CHEMBL925704

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against protease inhibitor-resistant HIV1 isolate

ChEMBL ↗

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Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

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Primary target Human immunodeficiency virus 1

CHEMBL378

Anchored from Assay target.

Protein identity Human immunodeficiency virus 1

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus 1
Confidence	1 — Organism
Curated By	Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus 1

Publication

Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV.

Ghosh AK, Dawson ZL, Mitsuya H.
Bioorg Med Chem (2007) 15 : 7576 -7580
PubMed 17900913 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	7.47	7.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL254841	—	—	1	7.47

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL254841	—	EC50	=	34.0	nM	7.47