Assay Detail
Binding
CHEMBL925845
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Inhibition of human URAT1-mediated urate uptake in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.13 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 6.52 |
| CHEMBL28626 | MORIN | — | 1 | 5.70 |
| CHEMBL897 | PROBENECID | 4.0 | 1 | 4.30 |
| CHEMBL832 | SULFINPYRAZONE | 4.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL28626 | MORIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL897 | PROBENECID | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL832 | SULFINPYRAZONE | IC50 | = | 100000.0 | nM | 4.00 |