Assay Detail
Functional
CHEMBL925885
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Cytotoxicity against taxol-resistant human NCI/ADR cells after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 10,11-dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.83 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | — | 1 | 8.01 |
| CHEMBL364447 | DISERMOLIDE | 2.0 | 1 | 6.80 |
| CHEMBL257328 | — | — | 1 | 6.52 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226880 | DICTYOSTATIN | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL364447 | DISERMOLIDE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL257328 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1000.0 | nM | 6.00 |