Assay Detail
Functional
CHEMBL925889
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Pseudomonas aeruginosa QscR expressed in Escherichia coli assessed as production of beta-galactosidase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Pseudomonas aeruginosa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.85 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8755 | — | — | 1 | 8.30 |
| CHEMBL8799 | — | — | 1 | 8.22 |
| CHEMBL463321 | — | — | 1 | 7.96 |
| CHEMBL8483 | — | — | 1 | 7.66 |
| CHEMBL8463 | — | — | 1 | 7.11 |
| CHEMBL259352 | — | — | 1 | - |
| CHEMBL441888 | — | — | 1 | - |
| CHEMBL408078 | — | — | 1 | - |
| CHEMBL264944 | — | — | 1 | - |
| CHEMBL264694 | — | — | 1 | - |
| CHEMBL408326 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8755 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL8799 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL463321 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL8483 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL8463 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL259352 | — | EC50 | - | — | - | |
| CHEMBL441888 | — | EC50 | - | — | - | |
| CHEMBL408078 | — | EC50 | - | — | - | |
| CHEMBL264944 | — | EC50 | - | — | - | |
| CHEMBL264694 | — | EC50 | - | — | - | |
| CHEMBL408326 | — | EC50 | - | — | - |