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Assay Detail

CHEMBL925910

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Functional
Antimalarial activity against Plasmodium falciparum D6
ChEMBL ↗
43
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials.
Opsenica I, Opsenica D, Smith KS, Milhous WK, Solaja BA.
J Med Chem (2008) 51 : 2261 -2266
PubMed 18330976 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 7.71 8.13
IC90 20 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL416956 MEFLOQUINE 4.0 2 8.13
CHEMBL261290 — — 2 8.07
CHEMBL269671 ARTEMISININ 3.0 2 8.05
CHEMBL259648 — — 2 8.03
CHEMBL262595 — — 2 8.01
CHEMBL260595 — — 2 7.95
CHEMBL259647 — — 2 7.95
CHEMBL260401 — — 2 7.89
CHEMBL76 CHLOROQUINE 4.0 2 7.88
CHEMBL259649 — — 2 7.86
CHEMBL260275 — — 2 7.82
CHEMBL260466 — — 2 7.81
CHEMBL406838 — — 2 7.80
CHEMBL258873 — — 2 7.71
CHEMBL264440 — — 1 7.67
CHEMBL260359 — — 2 7.62
CHEMBL406866 — — 2 7.62
CHEMBL261769 — — 2 7.54
CHEMBL257183 — — 1 7.51
CHEMBL258800 — — 2 7.33
CHEMBL403719 — — 2 6.89
CHEMBL261770 — — 2 6.37
CHEMBL260276 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL416956 MEFLOQUINE IC50 = 7.34 nM 8.13
CHEMBL261290 — IC50 = 8.6 nM 8.07
CHEMBL269671 ARTEMISININ IC50 = 9.0 nM 8.05
CHEMBL259648 — IC50 = 9.4 nM 8.03
CHEMBL262595 — IC50 = 9.87 nM 8.01
CHEMBL259647 — IC50 = 11.18 nM 7.95
CHEMBL260595 — IC50 = 11.24 nM 7.95
CHEMBL260401 — IC50 = 12.84 nM 7.89
CHEMBL76 CHLOROQUINE IC50 = 13.17 nM 7.88
CHEMBL259649 — IC50 = 13.82 nM 7.86
CHEMBL260275 — IC50 = 15.18 nM 7.82
CHEMBL260466 — IC50 = 15.64 nM 7.81
CHEMBL406838 — IC50 = 15.92 nM 7.80
CHEMBL258873 — IC50 = 19.27 nM 7.71
CHEMBL264440 — IC50 = 21.47 nM 7.67
CHEMBL260359 — IC50 = 24.12 nM 7.62
CHEMBL406866 — IC50 = 23.96 nM 7.62
CHEMBL261769 — IC50 = 29.2 nM 7.54
CHEMBL257183 — IC50 = 30.57 nM 7.51
CHEMBL258800 — IC50 = 46.77 nM 7.33
CHEMBL403719 — IC50 = 129.72 nM 6.89
CHEMBL261770 — IC50 = 429.27 nM 6.37
CHEMBL259649 — IC90 = 34.52 nM -
CHEMBL261769 — IC90 = 83.92 nM -
CHEMBL269671 ARTEMISININ IC90 = 12.8 nM -
CHEMBL76 CHLOROQUINE IC90 = 17.58 nM -
CHEMBL416956 MEFLOQUINE IC90 = 19.49 nM -
CHEMBL261290 — IC90 = 13.31 nM -
CHEMBL258800 — IC90 = 109.81 nM -
CHEMBL260359 — IC90 = 49.29 nM -
CHEMBL260466 — IC90 = 28.67 nM -
CHEMBL406838 — IC90 = 28.4 nM -
CHEMBL403719 — IC90 = 623.3 nM -
CHEMBL261770 — IC90 = 467.17 nM -
CHEMBL259648 — IC90 = 14.54 nM -
CHEMBL259647 — IC90 = 14.02 nM -
CHEMBL260401 — IC90 = 24.14 nM -
CHEMBL260276 — IC50 > 499.41 nM -
CHEMBL262595 — IC90 = 20.34 nM -
CHEMBL406866 — IC90 = 42.75 nM -
CHEMBL260275 — IC90 = 22.52 nM -
CHEMBL258873 — IC90 = 49.17 nM -
CHEMBL260595 — IC90 = 15.1 nM -