Assay Detail
Functional
CHEMBL925912
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Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235
41
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Chemical stability of the peroxide bond enables diversified synthesis of potent tetraoxane antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.60 | 8.14 |
| IC90 | 20 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260595 | — | — | 2 | 8.14 |
| CHEMBL259648 | — | — | 2 | 8.03 |
| CHEMBL259647 | — | — | 2 | 7.97 |
| CHEMBL262595 | — | — | 2 | 7.95 |
| CHEMBL260275 | — | — | 2 | 7.90 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 2 | 7.88 |
| CHEMBL259649 | — | — | 2 | 7.86 |
| CHEMBL261290 | — | — | 2 | 7.86 |
| CHEMBL260466 | — | — | 2 | 7.74 |
| CHEMBL406838 | — | — | 2 | 7.72 |
| CHEMBL260401 | — | — | 2 | 7.70 |
| CHEMBL260359 | — | — | 2 | 7.68 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 7.65 |
| CHEMBL258873 | — | — | 2 | 7.60 |
| CHEMBL261769 | — | — | 2 | 7.57 |
| CHEMBL406866 | — | — | 2 | 7.57 |
| CHEMBL258800 | — | — | 2 | 7.30 |
| CHEMBL403719 | — | — | 2 | 6.78 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.61 |
| CHEMBL261770 | — | — | 2 | 6.39 |
| CHEMBL260276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260595 | — | IC50 | = | 7.24 | nM | 8.14 |
| CHEMBL259648 | — | IC50 | = | 9.27 | nM | 8.03 |
| CHEMBL259647 | — | IC50 | = | 10.78 | nM | 7.97 |
| CHEMBL262595 | — | IC50 | = | 11.29 | nM | 7.95 |
| CHEMBL260275 | — | IC50 | = | 12.62 | nM | 7.90 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 13.04 | nM | 7.88 |
| CHEMBL261290 | — | IC50 | = | 13.93 | nM | 7.86 |
| CHEMBL259649 | — | IC50 | = | 13.89 | nM | 7.86 |
| CHEMBL260466 | — | IC50 | = | 18.15 | nM | 7.74 |
| CHEMBL406838 | — | IC50 | = | 19.24 | nM | 7.72 |
| CHEMBL260401 | — | IC50 | = | 19.75 | nM | 7.70 |
| CHEMBL260359 | — | IC50 | = | 20.77 | nM | 7.68 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 22.45 | nM | 7.65 |
| CHEMBL258873 | — | IC50 | = | 25.34 | nM | 7.60 |
| CHEMBL261769 | — | IC50 | = | 26.96 | nM | 7.57 |
| CHEMBL406866 | — | IC50 | = | 27.24 | nM | 7.57 |
| CHEMBL258800 | — | IC50 | = | 49.67 | nM | 7.30 |
| CHEMBL403719 | — | IC50 | = | 165.77 | nM | 6.78 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 244.76 | nM | 6.61 |
| CHEMBL261770 | — | IC50 | = | 410.58 | nM | 6.39 |
| CHEMBL261769 | — | IC90 | = | 110.22 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC90 | = | 17.4 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 345.08 | nM | - |
| CHEMBL416956 | MEFLOQUINE | IC90 | = | 50.14 | nM | - |
| CHEMBL261290 | — | IC90 | = | 20.56 | nM | - |
| CHEMBL258800 | — | IC90 | = | 88.09 | nM | - |
| CHEMBL260359 | — | IC90 | = | 73.88 | nM | - |
| CHEMBL260466 | — | IC90 | = | 27.19 | nM | - |
| CHEMBL406838 | — | IC90 | = | 29.31 | nM | - |
| CHEMBL403719 | — | IC90 | = | 339.88 | nM | - |
| CHEMBL259649 | — | IC90 | = | 39.51 | nM | - |
| CHEMBL259648 | — | IC90 | = | 16.73 | nM | - |
| CHEMBL259647 | — | IC90 | = | 13.93 | nM | - |
| CHEMBL260401 | — | IC90 | = | 28.98 | nM | - |
| CHEMBL262595 | — | IC90 | = | 22.24 | nM | - |
| CHEMBL260276 | — | IC50 | > | 499.41 | nM | - |
| CHEMBL406866 | — | IC90 | = | 55.62 | nM | - |
| CHEMBL260275 | — | IC90 | = | 23.66 | nM | - |
| CHEMBL258873 | — | IC90 | = | 53.89 | nM | - |
| CHEMBL260595 | — | IC90 | = | 12.79 | nM | - |
| CHEMBL261770 | — | IC90 | = | 522.55 | nM | - |