Assay Detail
Binding
CHEMBL926066
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Displacement of [3H]L685458 from gamma-secretase in human THP1 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.25 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302004 | — | — | 1 | 8.37 |
| CHEMBL255473 | — | — | 1 | 8.06 |
| CHEMBL247361 | — | — | 1 | 6.29 |
| CHEMBL429441 | — | — | 1 | 5.97 |
| CHEMBL247471 | — | — | 1 | 4.59 |
| CHEMBL18797 | SULINDAC SULFIDE | -1.0 | 1 | 4.24 |
| CHEMBL255682 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302004 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL255473 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL247361 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL429441 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL247471 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL18797 | SULINDAC SULFIDE | IC50 | = | 57100.0 | nM | 4.24 |
| CHEMBL255682 | — | IC50 | > | 100000.0 | nM | - |