Assay Detail
Binding
CHEMBL926151
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Inhibition of HDAC4 expressed in 293T cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | 293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Interaction of aliphatic cap group in inhibition of histone deacetylases by cyclic tetrapeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.45 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238829 | — | — | 1 | 7.75 |
| CHEMBL404172 | — | — | 1 | 7.70 |
| CHEMBL253308 | — | — | 1 | 7.64 |
| CHEMBL401837 | — | — | 1 | 7.62 |
| CHEMBL253309 | — | — | 1 | 7.48 |
| CHEMBL238596 | — | — | 1 | 7.28 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238829 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL404172 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL253308 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL401837 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL253309 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL238596 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 200.0 | nM | 6.70 |