Assay Detail
ADMET
CHEMBL926268
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Inhibition of CYP1A2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.36 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | — | 1 | 8.22 |
| CHEMBL279564 | PYRENE | — | 1 | 8.15 |
| CHEMBL122532 | — | — | 1 | 7.96 |
| CHEMBL253346 | — | — | 1 | 7.22 |
| CHEMBL243664 | ACACETIN | — | 1 | 7.10 |
| CHEMBL40919 | KAEMPFERIDE | — | 1 | 5.52 |
| CHEMBL490170 | HOMOERIODICTYOL | — | 1 | - |
| CHEMBL342696 | POLYCHLORINATED BIPHENYL 126 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283196 | ALPHA-NAPHTHOFLAVONE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL279564 | PYRENE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL122532 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL253346 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL243664 | ACACETIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL40919 | KAEMPFERIDE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL490170 | HOMOERIODICTYOL | IC50 | > | 4000.0 | nM | - |
| CHEMBL342696 | POLYCHLORINATED BIPHENYL 126 | IC50 | - | — | - |