Assay Detail
Binding
CHEMBL926489
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Inhibition of human recombinant GSKbeta
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.01 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612054 | — | — | 1 | 5.32 |
| CHEMBL252520 | 12,13-DEHYDRO-8-O-ACETYLMANZAMINE A | — | 1 | 5.32 |
| CHEMBL268202 | 12,13-DEHYDROMANZAMINE A | — | 1 | 5.27 |
| CHEMBL400717 | — | — | 1 | 5.14 |
| CHEMBL399696 | — | — | 1 | 5.07 |
| CHEMBL403233 | MANZAMINE A | — | 1 | 4.99 |
| CHEMBL403562 | 9-N-ETHYL-8-ETHOXY-MANZAMINE A | — | 1 | 4.98 |
| CHEMBL252672 | — | — | 1 | 4.78 |
| CHEMBL414128 | — | — | 1 | 4.64 |
| CHEMBL399493 | MANZAMINE E | — | 1 | 4.60 |
| CHEMBL437596 | TETRAHYDROMANZAMINE A | — | 1 | - |
| CHEMBL399694 | MANZAMINE F | — | 1 | - |
| CHEMBL253510 | TETRAHYDRO-8-HYDROXYMANZAMINE A | — | 1 | - |
| CHEMBL253548 | 6-Deoxymanzamine X | — | 1 | - |
| CHEMBL254391 | — | — | 1 | - |
| CHEMBL592630 | — | — | 1 | - |
| CHEMBL402273 | 9-N-ISOBUTYL-8-ISOBUTYLOXY-MANZAMINE A | — | 1 | - |
| CHEMBL267700 | 9-N-METHYL-8-METHOXY-MANZAMINE A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612054 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL252520 | 12,13-DEHYDRO-8-O-ACETYLMANZAMINE A | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL268202 | 12,13-DEHYDROMANZAMINE A | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL400717 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL399696 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL403233 | MANZAMINE A | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL403562 | 9-N-ETHYL-8-ETHOXY-MANZAMINE A | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL252672 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL414128 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL399493 | MANZAMINE E | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL437596 | TETRAHYDROMANZAMINE A | IC50 | - | — | - | |
| CHEMBL399694 | MANZAMINE F | IC50 | - | — | - | |
| CHEMBL253510 | TETRAHYDRO-8-HYDROXYMANZAMINE A | IC50 | - | — | - | |
| CHEMBL253548 | 6-Deoxymanzamine X | IC50 | - | — | - | |
| CHEMBL254391 | — | IC50 | - | — | - | |
| CHEMBL592630 | — | IC50 | - | — | - | |
| CHEMBL402273 | 9-N-ISOBUTYL-8-ISOBUTYLOXY-MANZAMINE A | IC50 | - | — | - | |
| CHEMBL267700 | 9-N-METHYL-8-METHOXY-MANZAMINE A | IC50 | - | — | - |