Assay Detail
ADMET
CHEMBL926646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SK-MN-C cells by MTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships of novel iron chelators for the treatment of iron overload disease: the methyl pyrazinylketone isonicotinoyl hydrazone series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.62 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385064 | — | — | 1 | 9.00 |
| CHEMBL254028 | — | — | 1 | 6.62 |
| CHEMBL254030 | — | — | 1 | 6.62 |
| CHEMBL254029 | — | — | 1 | 6.58 |
| CHEMBL399687 | — | — | 1 | 6.52 |
| CHEMBL231616 | TRIAPINE | 3.0 | 1 | 6.18 |
| CHEMBL390195 | — | — | 1 | 6.08 |
| CHEMBL238648 | — | — | 1 | 6.08 |
| CHEMBL254449 | — | — | 1 | 6.02 |
| CHEMBL399511 | — | — | 1 | 5.94 |
| CHEMBL251955 | — | — | 1 | 5.94 |
| CHEMBL253594 | — | — | 1 | 5.91 |
| CHEMBL253595 | — | — | 1 | 5.86 |
| CHEMBL440238 | METHYL PYRAZINYLKETONE THIOPHENECARBOXYL HYDRAZONE | — | 1 | 5.67 |
| CHEMBL239970 | — | — | 1 | 5.52 |
| CHEMBL253589 | METHYL PYRAZINYLKETONE BENZOYL HYDRAZONE | — | 1 | 5.44 |
| CHEMBL253588 | METHYL PYRAZINYLKETONE ISONICOTINOYL HYDRAZONE | — | 1 | 5.24 |
| CHEMBL399686 | — | — | 1 | 5.12 |
| CHEMBL254027 | — | — | 1 | 5.12 |
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 4.92 |
| CHEMBL254856 | — | — | 1 | 4.87 |
| CHEMBL253440 | — | — | 1 | 4.78 |
| CHEMBL400912 | — | — | 1 | 4.75 |
| CHEMBL252151 | — | — | 1 | 4.72 |
| CHEMBL400913 | — | — | 1 | 4.65 |
| CHEMBL255068 | — | — | 1 | 4.64 |
| CHEMBL255067 | — | — | 1 | 4.45 |
| CHEMBL253593 | — | — | 1 | 4.23 |
| CHEMBL252153 | — | — | 1 | - |
| CHEMBL252152 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385064 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL254028 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL254030 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL254029 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL399687 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL231616 | TRIAPINE | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL390195 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL238648 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL254449 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL399511 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL251955 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL253594 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL253595 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL440238 | METHYL PYRAZINYLKETONE THIOPHENECARBOXYL HYDRAZONE | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL239970 | — | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL253589 | METHYL PYRAZINYLKETONE BENZOYL HYDRAZONE | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL253588 | METHYL PYRAZINYLKETONE ISONICOTINOYL HYDRAZONE | IC50 | = | 5790.0 | nM | 5.24 |
| CHEMBL399686 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL254027 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 12050.0 | nM | 4.92 |
| CHEMBL254856 | — | IC50 | = | 13540.0 | nM | 4.87 |
| CHEMBL253440 | — | IC50 | = | 16760.0 | nM | 4.78 |
| CHEMBL400912 | — | IC50 | = | 17660.0 | nM | 4.75 |
| CHEMBL252151 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL400913 | — | IC50 | = | 22390.0 | nM | 4.65 |
| CHEMBL255068 | — | IC50 | = | 22660.0 | nM | 4.64 |
| CHEMBL255067 | — | IC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL253593 | — | IC50 | = | 58780.0 | nM | 4.23 |
| CHEMBL252153 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL252152 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL401362 | — | IC50 | > | 80000.0 | nM | - |