Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL926651

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human factor 10a
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Coagulation factor X (CHEMBL244)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

7-fluoroindazoles as potent and selective inhibitors of factor Xa.
Lee YK, Parks DJ, Lu T, Thieu TV, Markotan T, Pan W, McComsey DF, Milkiewicz KL, Crysler CS, Ninan N, Abad MC, Giardino EC, Maryanoff BE, Damiano BP, Player MR.
J Med Chem (2008) 51 : 282 -297
PubMed 18159923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 7.63 9.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL206335 RAZAXABAN 2.0 2 9.72
CHEMBL399163 1 8.85
CHEMBL255052 1 8.52
CHEMBL400504 1 8.39
CHEMBL255053 1 8.36
CHEMBL251939 1 8.31
CHEMBL223042 1 8.28
CHEMBL254831 1 8.19
CHEMBL252341 1 8.09
CHEMBL398870 1 7.80
CHEMBL254621 1 7.64
CHEMBL254620 1 7.58
CHEMBL400734 1 6.91
CHEMBL400306 1 6.83
CHEMBL402927 1 6.65
CHEMBL251938 1 6.64
CHEMBL401151 1 6.16
CHEMBL252540 1 5.65
CHEMBL254411 1 5.16
CHEMBL254410 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL206335 RAZAXABAN Ki = 0.19 nM 9.72
CHEMBL399163 Ki = 1.4 nM 8.85
CHEMBL206335 RAZAXABAN Ki = 1.6 nM 8.80
CHEMBL255052 Ki = 3.0 nM 8.52
CHEMBL400504 Ki = 4.1 nM 8.39
CHEMBL255053 Ki = 4.4 nM 8.36
CHEMBL251939 Ki = 4.9 nM 8.31
CHEMBL223042 Ki = 5.2 nM 8.28
CHEMBL254831 Ki = 6.4 nM 8.19
CHEMBL252341 Ki = 8.1 nM 8.09
CHEMBL398870 Ki = 15.9 nM 7.80
CHEMBL254621 Ki = 22.9 nM 7.64
CHEMBL254620 Ki = 26.0 nM 7.58
CHEMBL400734 Ki = 124.0 nM 6.91
CHEMBL400306 Ki = 147.0 nM 6.83
CHEMBL402927 Ki = 223.0 nM 6.65
CHEMBL251938 Ki = 231.0 nM 6.64
CHEMBL401151 Ki = 690.0 nM 6.16
CHEMBL252540 Ki = 2255.0 nM 5.65
CHEMBL254411 Ki = 6850.0 nM 5.16
CHEMBL254410 Ki > 14400.0 nM -