Assay Detail
Functional
CHEMBL926689
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei MITat 1.2 variant 221
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Trypanocidal and antileishmanial dihydrochelerythrine derivatives from Garcinia lucida.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.18 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | 4.0 | 1 | 8.60 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 6.70 |
| CHEMBL400359 | DIHYDROCHELERYTHRINE | — | 1 | 6.10 |
| CHEMBL250267 | — | — | 1 | 5.41 |
| CHEMBL252914 | LUCIDAMINE B | — | 1 | 5.39 |
| CHEMBL399861 | LUCIDAMINE A | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55 | PENTAMIDINE | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL265502 | SURAMIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL400359 | DIHYDROCHELERYTHRINE | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL250267 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL252914 | LUCIDAMINE B | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL399861 | LUCIDAMINE A | IC50 | = | 14100.0 | nM | 4.85 |