Assay Detail
Functional
CHEMBL926893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as reduction of virus-induced cytopathogenicity by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.89 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414850 | — | — | 1 | 8.33 |
| CHEMBL261703 | — | — | 1 | 4.92 |
| CHEMBL260778 | — | — | 1 | 4.41 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414850 | — | EC50 | = | 4.7 | nM | 8.33 |
| CHEMBL261703 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL260778 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL324842 | ROSMARINIC ACID | EC50 | > | 55000.0 | nM | - |