Assay Detail
Functional
CHEMBL926964
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Antiviral activity against HIV1 LAI in MT2 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.45 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206031 | BRECANAVIR | 2.0 | 1 | 9.70 |
| CHEMBL469086 | — | — | 1 | 9.52 |
| CHEMBL178593 | — | — | 1 | 9.40 |
| CHEMBL254349 | — | — | 1 | 8.85 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.47 |
| CHEMBL403306 | — | — | 1 | 8.30 |
| CHEMBL222559 | TIPRANAVIR | 4.0 | 1 | 7.00 |
| CHEMBL256107 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206031 | BRECANAVIR | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL469086 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL178593 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL254349 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1323 | DARUNAVIR | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL403306 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL222559 | TIPRANAVIR | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL256107 | — | IC50 | = | 480.0 | nM | 6.32 |