Assay Detail
Binding
CHEMBL927264
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PDBu from PKCepsilon C1B domain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.82 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399981 | — | — | 1 | 9.33 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 8.11 |
| CHEMBL401369 | — | — | 1 | 7.54 |
| CHEMBL206866 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399981 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL27266 | INDOLACTUM | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL401369 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL206866 | — | Ki | = | 510.0 | nM | 6.29 |