Assay Detail
Binding
CHEMBL927301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGS21680 from adenosine A1 receptor in bovine striatum membrane
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.20 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284969 | — | — | 1 | 6.14 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 5.91 |
| CHEMBL251997 | — | — | 1 | 5.34 |
| CHEMBL252198 | — | — | 1 | 5.33 |
| CHEMBL392149 | TECADENOSON | 2.0 | 1 | 5.14 |
| CHEMBL400189 | — | — | 1 | 5.14 |
| CHEMBL254271 | — | — | 1 | 5.10 |
| CHEMBL254481 | — | — | 1 | 5.09 |
| CHEMBL254897 | — | — | 1 | 5.00 |
| CHEMBL399306 | — | — | 1 | 4.96 |
| CHEMBL427718 | — | — | 1 | 4.89 |
| CHEMBL399514 | — | — | 1 | 4.82 |
| CHEMBL400330 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284969 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL251997 | — | Ki | = | 4560.0 | nM | 5.34 |
| CHEMBL252198 | — | Ki | = | 4689.0 | nM | 5.33 |
| CHEMBL392149 | TECADENOSON | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL400189 | — | Ki | = | 7230.0 | nM | 5.14 |
| CHEMBL254271 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL254481 | — | Ki | = | 8092.0 | nM | 5.09 |
| CHEMBL254897 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL399306 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL427718 | — | Ki | = | 12750.0 | nM | 4.89 |
| CHEMBL399514 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL400330 | — | Ki | = | 19300.0 | nM | 4.71 |