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Compound Detail

CHEMBL254897

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CCCNC(=S)OC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)nc(Cl)nc32)[C@](C)(O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL254897
Phase Preclinical
Structure Type MOL
InChI Key ZFTMOVFPLONUAZ-DIDGMBCJSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

487.0
MW (Da)
0.99
ALogP
11
HBA
4
HBD
135.8
PSA (Ų)
0.33
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H27ClN6O5S
MW 486.98
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness 0.22

Activity Summary

Ki 4 meas. best 6.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL4975
Ki 6.5 5.75 313.0 2
A1 adenosine receptor
CHEMBL1075029
Ki 5.84 5.365 1450.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17933541 10.1016/j.bmc.2007.09.035 Adenosine receptor A1 2
17933541 10.1016/j.bmc.2007.09.035 A1 adenosine receptor 2

Data from ChEMBL 36 via Core Engine