Assay Detail
Binding
CHEMBL927307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.23 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 6.10 |
| CHEMBL284969 | — | — | 1 | 5.64 |
| CHEMBL252198 | — | — | 1 | 5.34 |
| CHEMBL392149 | TECADENOSON | 2.0 | 1 | 5.19 |
| CHEMBL399514 | — | — | 1 | 5.06 |
| CHEMBL251997 | — | — | 1 | 5.02 |
| CHEMBL400189 | — | — | 1 | 4.98 |
| CHEMBL254064 | — | — | 1 | 4.98 |
| CHEMBL254896 | — | — | 1 | 4.80 |
| CHEMBL400782 | — | — | 1 | - |
| CHEMBL400190 | — | — | 1 | - |
| CHEMBL254693 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 794.0 | nM | 6.10 |
| CHEMBL284969 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL252198 | — | Ki | = | 4590.0 | nM | 5.34 |
| CHEMBL392149 | TECADENOSON | Ki | = | 6390.0 | nM | 5.19 |
| CHEMBL399514 | — | Ki | = | 8760.0 | nM | 5.06 |
| CHEMBL251997 | — | Ki | = | 9580.0 | nM | 5.02 |
| CHEMBL400189 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL254064 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL254896 | — | Ki | = | 15900.0 | nM | 4.80 |
| CHEMBL400782 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL400190 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL254693 | — | Ki | > | 100000.0 | nM | - |