Assay Detail
Binding
CHEMBL927398
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Binding affinity to beta amyloid plaque in human Alzheimer's disease brain tissue
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.27 | 8.10 |
| Kd | 1 | 8.14 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | 2.0 | 1 | 8.14 |
| CHEMBL252766 | — | — | 1 | 8.10 |
| CHEMBL78012 | — | — | 1 | 8.05 |
| CHEMBL252765 | — | — | 1 | 7.10 |
| CHEMBL252969 | — | — | 1 | 6.69 |
| CHEMBL254850 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93124 | PITTSBURGH COMPOUND B UNLABELLED | Kd | = | 7.23 | nM | 8.14 |
| CHEMBL252766 | — | Ki | = | 7.93 | nM | 8.10 |
| CHEMBL78012 | — | Ki | = | 8.95 | nM | 8.05 |
| CHEMBL252765 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL252969 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL254850 | — | Ki | = | 377.0 | nM | 6.42 |