Assay Detail
Binding
CHEMBL927607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine PNMT by radiochemical assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Phenylethanolamine N-methyltransferase (CHEMBL2331) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.30 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 8.51 |
| CHEMBL281864 | — | — | 1 | 7.25 |
| CHEMBL357424 | — | — | 1 | 7.17 |
| CHEMBL59719 | — | — | 1 | 7.14 |
| CHEMBL281289 | — | — | 1 | 6.92 |
| CHEMBL26717 | — | — | 1 | 6.55 |
| CHEMBL60434 | — | — | 1 | 5.85 |
| CHEMBL27162 | — | — | 1 | 5.82 |
| CHEMBL26711 | — | — | 1 | 5.70 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 5.30 |
| CHEMBL26879 | — | — | 1 | 5.30 |
| CHEMBL28228 | — | — | 1 | 4.14 |
| CHEMBL610 | PHENETHYLAMINE | — | 1 | - |
| CHEMBL522 | BENZYLAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL281864 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL357424 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL59719 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL281289 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL26717 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL60434 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL27162 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL26711 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL26879 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL28228 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL610 | PHENETHYLAMINE | Ki | = | 220000.0 | nM | - |
| CHEMBL522 | BENZYLAMINE | Ki | = | 170000.0 | nM | - |