Assay Detail
Binding
CHEMBL927859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MMP9
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.94 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404409 | — | — | 1 | 7.66 |
| CHEMBL251820 | — | — | 1 | 7.60 |
| CHEMBL399351 | — | — | 1 | 7.11 |
| CHEMBL252627 | — | — | 1 | 7.00 |
| CHEMBL254295 | — | — | 1 | 6.27 |
| CHEMBL254510 | — | — | 1 | 6.02 |
| CHEMBL252024 | — | — | 1 | - |
| CHEMBL253665 | — | — | 1 | - |
| CHEMBL253035 | — | — | 1 | - |
| CHEMBL256157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404409 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL251820 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL399351 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL252627 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL254295 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL254510 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL252024 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL253665 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL253035 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL256157 | — | IC50 | < | 1.5 | nM | - |