Assay Detail
Binding
CHEMBL928082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at rat cloned iGluR6 expressed in human HEK293 cells by calcium imaging assay
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 2 (CHEMBL3607) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.15 | 4.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 2 | 4.23 |
| CHEMBL260328 | — | — | 2 | 4.09 |
| CHEMBL260327 | — | — | 1 | - |
| CHEMBL30285 | IBOTENIC ACID | — | 1 | - |
| CHEMBL260122 | — | — | 1 | - |
| CHEMBL406621 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 58884.37 | nM | 4.23 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL260328 | — | EC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL260328 | — | EC50 | = | 81283.05 | nM | 4.09 |
| CHEMBL260327 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL30285 | IBOTENIC ACID | EC50 | > | 1000000.0 | nM | - |
| CHEMBL260122 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL406621 | — | EC50 | > | 1000000.0 | nM | - |