Assay Detail
Functional
CHEMBL928084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at rat cloned mGluR2 expressed in CHO cells assessed as effect on cAMP accumulation
10
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.04 | 4.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260122 | — | — | 2 | 4.08 |
| CHEMBL408899 | TRICHOLOMIC ACID | — | 3 | 4.00 |
| CHEMBL260328 | — | — | 1 | - |
| CHEMBL406621 | — | — | 1 | - |
| CHEMBL260327 | — | — | 1 | - |
| CHEMBL30285 | IBOTENIC ACID | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260122 | — | EC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL260122 | — | EC50 | = | 83176.38 | nM | 4.08 |
| CHEMBL408899 | TRICHOLOMIC ACID | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL408899 | TRICHOLOMIC ACID | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL260328 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL406621 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL260327 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL30285 | IBOTENIC ACID | EC50 | = | 110000.0 | nM | - |
| CHEMBL30285 | IBOTENIC ACID | EC50 | = | 107151.93 | nM | - |
| CHEMBL408899 | TRICHOLOMIC ACID | EC50 | > | 1000000.0 | nM | - |