Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL928085

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Activity at rat cloned mGluR1a expressed in CHO cells assessed as effect on cAMP accumulation
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Metabotropic glutamate receptor 1 (CHEMBL4477)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.
Pinto A, Conti P, De Amici M, Tamborini L, Madsen U, Nielsen B, Christesen T, Bräuner-Osborne H, De Micheli C.
J Med Chem (2008) 51 : 2311 -2315
PubMed 18338843 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 4.23 4.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL30285 IBOTENIC ACID 2 4.37
CHEMBL260122 2 4.09
CHEMBL260327 1 -
CHEMBL260328 2 -
CHEMBL406621 1 -
CHEMBL408899 TRICHOLOMIC ACID 4 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL30285 IBOTENIC ACID EC50 = 43000.0 nM 4.37
CHEMBL260122 EC50 = 82000.0 nM 4.09
CHEMBL260327 EC50 > 1000000.0 nM -
CHEMBL260328 EC50 = 610000.0 nM -
CHEMBL260328 EC50 = 1737800828749.38 nM -
CHEMBL30285 IBOTENIC ACID EC50 = 23442288153199.27 nM -
CHEMBL260122 EC50 = 12589254117941.66 nM -
CHEMBL406621 EC50 > 1000000.0 nM -
CHEMBL408899 TRICHOLOMIC ACID EC50 = 790000.0 nM -
CHEMBL408899 TRICHOLOMIC ACID EC50 = 1258925411794.17 nM -
CHEMBL408899 TRICHOLOMIC ACID EC50 = 110000.0 nM -
CHEMBL408899 TRICHOLOMIC ACID EC50 = 12589254117941.66 nM -