Assay Detail
Binding
CHEMBL928087
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Inhibition of glutathione-S-transferase activity of prostaglandin D2 synthase
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Hematopoietic prostaglandin D synthase (CHEMBL5879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel prostaglandin D synthase inhibitors generated by fragment-based drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.37 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261777 | — | — | 1 | 7.68 |
| CHEMBL258506 | — | — | 1 | 7.12 |
| CHEMBL258467 | — | — | 1 | 6.86 |
| CHEMBL265720 | — | — | 1 | 6.04 |
| CHEMBL264951 | — | — | 1 | 6.00 |
| CHEMBL442461 | — | — | 1 | 5.82 |
| CHEMBL261693 | — | — | 1 | 5.42 |
| CHEMBL127757 | — | — | 1 | 5.42 |
| CHEMBL415324 | TRANILAST | 3.0 | 1 | 4.94 |
| CHEMBL260489 | — | — | 1 | 4.91 |
| CHEMBL261678 | — | — | 1 | 4.76 |
| CHEMBL408265 | — | — | 1 | 4.58 |
| CHEMBL405844 | — | — | 1 | 4.48 |
| CHEMBL260289 | — | — | 1 | 4.46 |
| CHEMBL260488 | — | — | 1 | 4.35 |
| CHEMBL406105 | — | — | 1 | 3.05 |
| CHEMBL264950 | — | — | 1 | - |
| CHEMBL263379 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261777 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL258506 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL258467 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL265720 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL264951 | — | IC50 | = | 994.0 | nM | 6.00 |
| CHEMBL442461 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL261693 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL127757 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL415324 | TRANILAST | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL260489 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL261678 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL408265 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL405844 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL260289 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL260488 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL406105 | — | IC50 | = | 890000.0 | nM | 3.05 |
| CHEMBL264950 | — | IC50 | - | — | - | |
| CHEMBL263379 | — | IC50 | - | — | - |