Assay Detail
Binding
CHEMBL928097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]naloxone from mu opioid receptor in rat brain membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.75 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 5.01 |
| CHEMBL409225 | — | — | 1 | 4.68 |
| CHEMBL260120 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | IC50 | = | 9770.0 | nM | 5.01 |
| CHEMBL409225 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL260120 | — | IC50 | = | 28100.0 | nM | 4.55 |