Assay Detail
Binding
CHEMBL928170
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Inhibition of cKit
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.44 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260092 | — | — | 1 | 8.22 |
| CHEMBL411903 | — | — | 1 | 7.96 |
| CHEMBL403706 | — | — | 1 | 7.92 |
| CHEMBL409872 | — | — | 1 | 7.75 |
| CHEMBL429516 | — | — | 1 | 7.66 |
| CHEMBL410731 | — | — | 1 | 7.55 |
| CHEMBL259013 | — | — | 1 | 7.46 |
| CHEMBL262607 | — | — | 1 | 7.43 |
| CHEMBL412102 | — | — | 1 | 7.30 |
| CHEMBL260848 | — | — | 1 | 7.04 |
| CHEMBL263374 | — | — | 1 | 5.52 |
| CHEMBL260093 | — | — | 1 | - |
| CHEMBL409839 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260092 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL411903 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL403706 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL409872 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL429516 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL410731 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL259013 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL262607 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL412102 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL260848 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL263374 | — | IC50 | = | 3022.0 | nM | 5.52 |
| CHEMBL260093 | — | IC50 | - | — | - | |
| CHEMBL409839 | — | IC50 | > | 13000.0 | nM | - |