Assay Detail
Functional
CHEMBL928263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse NIH3T3 cells by [3H]thymidine assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.67 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406411 | — | — | 1 | 7.70 |
| CHEMBL411855 | — | — | 1 | 7.29 |
| CHEMBL409331 | — | — | 1 | 7.27 |
| CHEMBL411297 | — | — | 1 | 7.14 |
| CHEMBL261454 | — | — | 1 | 7.09 |
| CHEMBL261674 | — | — | 1 | 7.04 |
| CHEMBL409525 | — | — | 1 | 7.01 |
| CHEMBL261762 | — | — | 1 | 7.01 |
| CHEMBL260015 | — | — | 1 | 6.68 |
| CHEMBL409158 | — | — | 1 | 6.60 |
| CHEMBL260240 | — | — | 1 | 6.59 |
| CHEMBL260923 | — | — | 1 | 6.47 |
| CHEMBL260147 | — | — | 1 | 6.38 |
| CHEMBL409356 | — | — | 1 | 6.14 |
| CHEMBL411741 | — | — | 1 | 5.99 |
| CHEMBL410308 | — | — | 1 | 5.64 |
| CHEMBL261702 | — | — | 1 | 5.29 |
| CHEMBL260239 | — | — | 1 | - |
| CHEMBL261625 | — | — | 1 | - |
| CHEMBL408181 | — | — | 1 | - |
| CHEMBL409515 | — | — | 1 | - |
| CHEMBL259169 | — | — | 1 | - |
| CHEMBL258964 | — | — | 1 | - |
| CHEMBL261701 | — | — | 1 | - |
| CHEMBL406407 | — | — | 1 | - |
| CHEMBL260729 | — | — | 1 | - |
| CHEMBL258641 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406411 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL411855 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL409331 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL411297 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL261454 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL261674 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL409525 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL261762 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL260015 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL409158 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL260240 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL260923 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL260147 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL409356 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL411741 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL410308 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL261702 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL260239 | — | IC50 | - | — | - | |
| CHEMBL261625 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL408181 | — | IC50 | - | — | - | |
| CHEMBL409515 | — | IC50 | - | — | - | |
| CHEMBL259169 | — | IC50 | - | — | - | |
| CHEMBL258964 | — | IC50 | - | — | - | |
| CHEMBL261701 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL406407 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL260729 | — | IC50 | - | — | - | |
| CHEMBL258641 | — | IC50 | - | — | - |