Assay Detail
Binding
CHEMBL928491
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Inhibition of Akt1
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of pyridopyrimidines as potent Akt1/2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.36 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254099 | — | — | 1 | 8.42 |
| CHEMBL253693 | — | — | 1 | 8.40 |
| CHEMBL404554 | — | — | 1 | 8.35 |
| CHEMBL252857 | — | — | 1 | 8.22 |
| CHEMBL404556 | — | — | 1 | 8.21 |
| CHEMBL403356 | — | — | 1 | 8.07 |
| CHEMBL252856 | — | — | 1 | 8.01 |
| CHEMBL253458 | — | — | 1 | 7.85 |
| CHEMBL252456 | — | — | 1 | 7.82 |
| CHEMBL253457 | — | — | 1 | 7.75 |
| CHEMBL404347 | — | — | 1 | 7.63 |
| CHEMBL404555 | — | — | 1 | 7.62 |
| CHEMBL252457 | — | — | 1 | 7.54 |
| CHEMBL252455 | — | — | 1 | 7.34 |
| CHEMBL252261 | — | — | 1 | 7.20 |
| CHEMBL404553 | — | — | 1 | 7.19 |
| CHEMBL252652 | — | — | 1 | 7.09 |
| CHEMBL403354 | — | — | 1 | 7.05 |
| CHEMBL252653 | — | — | 1 | 7.04 |
| CHEMBL252054 | — | — | 1 | 7.00 |
| CHEMBL252259 | — | — | 1 | 6.86 |
| CHEMBL252055 | — | — | 1 | 6.86 |
| CHEMBL403355 | — | — | 1 | 6.79 |
| CHEMBL252056 | — | — | 1 | 6.70 |
| CHEMBL276130 | — | — | 1 | 6.65 |
| CHEMBL252654 | — | — | 1 | 6.54 |
| CHEMBL251860 | — | — | 1 | 6.12 |
| CHEMBL252260 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254099 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL253693 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL404554 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL252857 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL404556 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL403356 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL252856 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL253458 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL252456 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL253457 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL404347 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL404555 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL252457 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL252455 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL252261 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL404553 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL252652 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL403354 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL252653 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL252054 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL252259 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL252055 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL403355 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL252056 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL276130 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL252654 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL251860 | — | IC50 | = | 765.0 | nM | 6.12 |
| CHEMBL252260 | — | IC50 | = | 1521.0 | nM | 5.82 |